New review: the bone marrow microenvironment as a barrier — and a target — in AML

We're delighted to share a new review from the lab, published in Blood and Lymphatic Cancer: Targets and Therapy. Led by PhD students Aleksandra Kolosova and Imogen Mould, it explores how the bone marrow microenvironment shapes acute myeloid leukaemia (AML) — acting both as a barrier that shields leukaemia cells from treatment and as a source of crosstalk that could itself be targeted therapeutically.

It maps the interactions between leukaemia cells and their surrounding niche, and asks how disrupting that relationship might make AML more vulnerable to therapy — a question at the heart of the lab's research.

It's a particularly proud milestone to see the review first-authored by Aleksandra and Imogen so early in their PhDs.

Read the review: Kolosova A, Mould I, Pepper C, Mitchell S, Pepper A, Ladikou E, Simoes F. Exploring the Bone Marrow Microenvironment as a Therapeutic Barrier and Targetable Source of Crosstalk in Acute Myeloid Leukemia. Blood and Lymphatic Cancer: Targets and Therapy, 2026, 16:1–25. https://doi.org/10.2147/BLCTT.S511758